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Abstract
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Abstract
BACKGROUND: The aim of our study is to
evaluate the stress markers at the patients with
rheumatoid arthritis that used Diseasemodifying antirheumatic drugs (DMARD)
medication.
METHODS: Blood taken from the patients
diagnosed with romatoid artrit according to
American Rheumatism Association ACR 2010
criteria, employed the medication of DMARD
in order to examine the stress parameters of
total oxidant status, total antioxidant status,
paraoxonase, paraoxonase NaCl, arylesterase,
myeloperoxidase, catalase, thiol concentration.
Besides, routine assessment of patient index
data 3 (RAPID3) activities of patients were
monitored.
Thirty seven patients with early RA and 61
healthy controls were included in the study,
and clinical examination and investigations
were performed and disease activity was
assessed. Peripheral blood samples were used
for all the assays.
RESULTS: The average age of the patients
were 46.52±12.37, and their average BMI was
28.93±4.81. The value of catalase was significantly higher at the experimental group
comparing to the control group; the values of
thiol, arylesterase, myeloperoksidase, total
oxidant status at experimental group were
significanly lower than the control group
(p<0.05). The patients rapid 3 values and other
oksidatif stres markers were not statistically
significantly different. (p>0.050).
CONCLUSİON: Stronger response in patients
with early RA suggests that oxidative stress
markers may be useful in evaluating the
progression of RA as well as in elucidating the
mechanisms of disease pathogenesis.