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Abstract
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Abstract
BACKGROUND:Hematological inflammatory
markers may be used as predictors for
prognosis of gastric cancer. The aim of this
study was to investigate the the association
between pre-treatment hematological
inflammatory markers and clinicopathological
features in the gastric cancer patients.
METHODS: We retrospectively enrolled 118
patients diagnosed with gastric cancer who
underwent surgery and received adjuvant
chemoradiation at the Department of
Radiation Oncology between July 2013 and
June 2023. Clinicopathologic features such as
age (≤50 and >50 years of age), sex, tumor
location (cardia, corpus, antrum), T and N
stage, histological type (adenocarcinoma, nonadencarcinoma), grade, lymphovascular
invasion (LVI), and perineural invasion (PNI)
were reviewed. Preoperative hematological
inflammatory markers are neutrophil,
lymphocyte, monocyte, platelet, mean platelet volume (MPV), plateletcrit, neutrophil to
lymphocyte ratio (NLR), lymphocyte to
monocyte ratio (LMR), and platelet to
lymphocyte ratio (PLR) were recorded.
RESULTS: Median age was 59 (23-85) years.
Median age for men (n=89) and women
(n=29) was 58 (29-85) and 61 (23-83) years,
respectively. NLR, LMR, and PLR were found
to be 2.8 (±1.51), 3.38 (±1.18), and 153.44
(±59.8), respectively. LMR was significantly
higher in patients ≤50 years of age compared
to those over 50 years (p= 0.02). While LMR
was 3.26 (±1.16) in the patients ≤50 years of
age, it was 3.86 (±1.15) in older ones.
Neutrophil values and NLR were found
moderately higher in men compared to women
[5.2 (±2.05) vs. 4.3(±1.8) and 2.95 (±1.6) vs.
2.3 (±1.2), respectively] (p=0.04). There was a
strong correlation between the T stage and
platelet values (p= 0.006). Platelet value was
found to be 167.5 (±61.3), 310.4 (±62.2), 270
(±56.1), and 275.2 (±71.2) in patients with T1, T2, T3, and T4, respectively. Other
hematological inflammatory markers were not
found to affect the clinicopathological features
of the gastric cancer patients.
CONCLUSIONS: LMR, NLR and platelets
are the hematological inflammatory markers
which present relationship with
clinicopathological features of the gastric
cancer patients.
